ZNF516 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q92618 |
Other Accession | NP_055458.1 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 124289 Da |
Antigen Region | 518-547 aa |
Gene ID | 9658 |
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Other Names | Zinc finger protein 516, ZNF516, KIAA0222 |
Target/Specificity | This ZNF516 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-547 amino acids from the Central region of human ZNF516. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZNF516 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZNF516 (HGNC:28990) |
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Function | Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q7TSH3}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNF516 may be involved in transcriptional regulation.
References
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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