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DNAI2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9GZS0 |
| Other Accession | NP_075462.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68821 Da |
| Antigen Region | 484-513 aa |
| Gene ID | 64446 |
|---|---|
| Other Names | Dynein intermediate chain 2, axonemal, Axonemal dynein intermediate chain 2, DNAI2 |
| Target/Specificity | This DNAI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-513 amino acids from the C-terminal region of human DNAI2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DNAI2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAI2 (HGNC:18744) |
|---|---|
| Function | Part of the dynein complex of respiratory cilia. |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Dynein axonemal particle {ECO:0000250|UniProtKB:Q4QR00}. Note=Located in the proximal region of respiratory cilia. |
| Tissue Location | Highly expressed in trachea and testis. Expressed in respiratory ciliated cells (at protein level) (PubMed:33139725) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Loges, N.T., et al. Am. J. Hum. Genet. 83(5):547-558(2008)
Pennarun, G., et al. Hum. Genet. 107(6):642-649(2000)
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