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RBP4 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RBP4 Antibody (N-term) AP20177A
    RBP4 Antibody (N-term) (Cat. #AP20177a) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the RBP4 antibody detected the RBP4 protein (arrow).
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  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P02753
Other Accession P04916, P27485, Q00724, NP_006735.2, Q28369
Reactivity Mouse
Predicted Horse, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 23010 Da
Antigen Region 11-40 aa
Additional Information
Gene ID 5950
Other Names Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4
Target/Specificity This RBP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human RBP4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRBP4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBP4
Function Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).
Cellular Location Secreted
Tissue Location Detected in blood plasma and in urine (at protein level).
Research Areas
Citations ( 0 )

Background

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.

References

Wang, S.N., et al. J. Formos. Med. Assoc. 109(6):422-429(2010)
Liu, X.H., et al. Zhonghua Yi Xue Za Zhi 90(18):1251-1254(2010)
Ku, Y.H., et al. J. Int. Med. Res. 38(3):782-791(2010)
Giacomozzi, C., et al. J. Endocrinol. Invest. 33(4):218-221(2010)
Nair, A.K., et al. PLoS ONE 5 (7), E11444 (2010) :

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$ 182.50
$ 70.00
Cat# AP20177A
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