|Application ||WB, E|
|Other Accession||Q17QM8, NP_008957.1|
|Calculated MW||22255 Da|
|Antigen Region||76-105 aa|
|Other Names||Dual specificity protein phosphatase 14, MKP-1-like protein tyrosine phosphatase, MKP-L, Mitogen-activated protein kinase phosphatase 6, MAP kinase phosphatase 6, MKP-6, DUSP14, MKP6|
|Target/Specificity||This DUSP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human DUSP14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUSP14 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.|
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Provided below are standard protocols that you may find useful for product applications.
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).
Thye, T., et al. Nat. Genet. 42(9):739-741(2010)
Lountos, G.T., et al. Acta Crystallogr. D Biol. Crystallogr. 65 (PT 10), 1013-1020 (2009) :
Patterson, K.I., et al. Biochem. J. 418(3):475-489(2009)
Elass, E., et al. FEBS Lett. 582(3):445-450(2008)
Nyati, M.K., et al. Cancer Res. 66(24):11554-11559(2006)
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