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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PPP2CA Antibody (Center)   

PPP2CA Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PPP2CA Antibody (Center) AP20181c
    PPP2CA Antibody (Center) (Cat. #AP20181c) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the PPP2CA antibody detected the PPP2CA protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P67775
Other Accession P23696, P63331, P67777, P67776, P63330, P67774, NP_002706.1
Reactivity Mouse
Predicted Bovine, Pig, Rabbit, Rat, Drosophila
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35594 Da
Antigen Region 88-116 aa
Additional Information
Gene ID 5515
Other Names Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, Replication protein C, RP-C, PPP2CA
Target/Specificity This PPP2CA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human PPP2CA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPP2CA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.
Cellular Location Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity).
Research Areas
Citations (0)

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This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Jayadeva, G., et al. J. Biol. Chem. 285(39):29863-29873(2010)
Pradhan, S., et al. J. Biol. Chem. 285(38):29059-29068(2010)
Schmitz, M.H., et al. Nat. Cell Biol. 12(9):886-893(2010)
Antony, R., et al. J. Biol. Chem. 285(24):18301-18308(2010)

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Cat# AP20181c
(40 western blots)
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