|Application ||WB, E|
|Calculated MW||24382 Da|
|Antigen Region||4-32 aa|
|Other Names||Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8|
|Target/Specificity||This RGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human RGS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.|
|Cellular Location||Isoform 1: Cell membrane. Cytoplasm. Nucleus, nucleolus Isoform 3: Cell membrane. Cytoplasm. Nucleus, nucleolus|
|Tissue Location||Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL)|
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Provided below are standard protocols that you may find useful for product applications.
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Miyamoto-Matsubara, M., et al. Ann. N. Y. Acad. Sci. 1200, 112-119 (2010) :
Li, N.F., et al. Clin. Exp. Hypertens. 32(5):256-261(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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