|Application ||WB, E|
|Other Accession||Q5XI81, Q61584, O70523, Q2TBT7, NP_005078.2|
|Predicted||Bovine, Hamster, Rat|
|Calculated MW||69721 Da|
|Antigen Region||37-66 aa|
|Other Names||Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1|
|Target/Specificity||This FXR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human FXR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FXR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity).|
|Tissue Location||Expressed in all tissues examined including heart, brain, kidney and testis.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
Coffee, R.L. Jr., et al. Dis Model Mech 3 (7-8), 471-485 (2010) :
Darnell, J.C., et al. Hum. Mol. Genet. 18(17):3164-3177(2009)
Purcell, S.M., et al. Nature 460(7256):748-752(2009)
Davidovic, L., et al. J. Med. Genet. 45(10):679-685(2008)
Vasudevan, S., et al. Cell 128(6):1105-1118(2007)
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