|Application ||WB, IHC-P, FC, E|
|Calculated MW||199526 Da|
|Other Names||Microtubule-associated protein 2, MAP-2, MAP2|
|Target/Specificity||This MAP2 antibody is generated from rabbits immunized with MAP2 recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
MAP2 encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development.
Maddodi, N., et al. J. Biol. Chem. 285(1):242-254(2010)
Krishnan, C., et al. Am. J. Surg. Pathol. 33(11):1695-1704(2009)
Gambichler, T., et al. Am. J. Clin. Pathol. 131(5):710-714(2009)
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
Romeike, B.F., et al. Histopathology 54(4):504-505(2009)
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