|Application ||WB, E|
|Calculated MW||38160 Da|
|Antigen Region||310-338 aa|
|Other Names||Protein atonal homolog 1, Class A basic helix-loop-helix protein 14, bHLHa14, Helix-loop-helix protein hATH-1, hATH1, ATOH1, ATH1, BHLHA14|
|Target/Specificity||This ATOH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-338 amino acids from the C-terminal region of human ATOH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATOH1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.
Kazanjian, A., et al. Gastroenterology 139(3):918-928(2010)
Heiskala, K., et al. Histol. Histopathol. 25(1):63-72(2010)
Maricich, S.M., et al. J. Neurosci. 29(36):11123-11133(2009)
Bossuyt, W., et al. PLoS Biol. 7 (2), E39 (2009) :
Aragaki, M., et al. Biochem. Biophys. Res. Commun. 368(4):923-929(2008)
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