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ATOH1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ATOH1 Antibody (C-term) AP20212b
    ATOH1 Antibody (C-term) (Cat. #AP20212b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the ATOH1 antibody detected the ATOH1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q92858
Other Accession NP_005163.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 310-338 aa
Additional Information
Other Names Protein atonal homolog 1, Class A basic helix-loop-helix protein 14, bHLHa14, Helix-loop-helix protein hATH-1, hATH1, ATOH1, ATH1, BHLHA14
Target/Specificity This ATOH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-338 amino acids from the C-terminal region of human ATOH1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsATOH1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATOH1
Synonyms ATH1, BHLHA14
Function Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).
Cellular Location Nucleus. EMBL; U61148; AAB41305.1; -; Genomic_DNA EMBL; BC069145; AAH69145.1; -; mRNA EMBL; BC069594; AAH69594.1; -; mRNA EMBL; BC069604; AAH69604.1; -; mRNA EMBL; BC113623; AAI13624.1; -; mRNA EMBL; BC113625; AAI13626.1; -; mRNA CCDS; CCDS3638.1; - RefSeq; NP_005163.1; NM_005172.1 UniGene; Hs.532680; - ProteinModelPortal; Q92858; - SMR; Q92858; - BioGrid; 106964; 75 STRING; 9606.ENSP00000302216; - iPTMnet; Q92858; - PhosphoSitePlus; Q92858; - BioMuta; ATOH1; - DMDM; 3913115; - PaxDb; Q92858; - PeptideAtlas; Q92858; - PRIDE; Q92858; - ProteomicsDB; 75551; - DNASU; 474; - Ensembl; ENST00000306011; ENSP00000302216; ENSG00000172238 GeneID; 474; - KEGG; hsa:474; - UCSC; uc003hta.2; human CTD; 474; - DisGeNET; 474; - EuPathDB; HostDB:ENSG00000172238.4; - GeneCards; ATOH1; - HGNC; HGNC:797; ATOH1 MIM; 601461; gene neXtProt; NX_Q92858; - OpenTargets; ENSG00000172238; - PharmGKB; PA25095; - eggNOG; KOG4395; Eukaryota eggNOG; ENOG411269K; LUCA GeneTree; ENSGT00680000099860; - HOGENOM; HOG000261611; - HOVERGEN; HBG050609; - InParanoid; Q92858; - KO; K09083; - OMA; KQVNGVQ; - OrthoDB; EOG091G0R1N; - PhylomeDB; Q92858; - TreeFam; TF315153; - SIGNOR; Q92858; - GeneWiki; ATOH1; - GenomeRNAi; 474; - PRO; PR:Q92858; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000172238; - CleanEx; HS_ATOH1; - Genevisible; Q92858; HS GO; GO:0005634; C:nucleus; ISS:UniProtKB GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl GO; GO:0003700; F:DNA binding transcription factor activity; TAS:ProtInc GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl GO; GO:0042668; P:auditory receptor cell fate determination; IEA:Ensembl GO; GO:0042667; P:auditory receptor cell fate specification; IEA:Ensembl GO; GO:0007411; P:axon guidance; IEA:Ensembl GO; GO:0007417; P:central nervous system development; TAS:ProtInc GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl GO; GO:0001764; P:neuron migration; IEA:Ensembl GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl GO; GO:0045609; P:positive regulation of inner ear auditory receptor cell differentiation; IEA:Ensembl GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc CDD; cd00083; HLH; 1 Gene3D; 4.10.280.10; -; 1 InterPro; IPR032661; ATOH1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf PANTHER; PTHR19290:SF82; PTHR19290:SF82; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 2: Evidence at transcript level; Activator; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation CHAIN 1 354 Protein atonal homolog 1 /FTId=PRO_0000127139 DOMAIN 159 211 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} COMPBIAS 29 38 Poly-Pro COMPBIAS 224 228 Poly-Pro VARIANT 237 237 H -> Q (in dbSNP:rs35182771) /FTId=VAR_049539 SEQUENCE 354 AA; 38160 MW; AB12F1E917A00A8D CRC64; MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS
Research Areas
Citations (0)

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Background

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.

References

Kazanjian, A., et al. Gastroenterology 139(3):918-928(2010)
Heiskala, K., et al. Histol. Histopathol. 25(1):63-72(2010)
Maricich, S.M., et al. J. Neurosci. 29(36):11123-11133(2009)
Bossuyt, W., et al. PLoS Biol. 7 (2), E39 (2009) :
Aragaki, M., et al. Biochem. Biophys. Res. Commun. 368(4):923-929(2008)

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$ 295.00
$ 99.00
Cat# AP20212b
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Quantity:
(40 western blots)
Availability: In Stock
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