|Application ||WB, E|
|Calculated MW||46337 Da|
|Antigen Region||341-370 aa|
|Other Names||F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3|
|Target/Specificity||This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXW4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.|
|Tissue Location||Expressed in brain, kidney, lung and liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
Everman, D.B., et al. Am. J. Med. Genet. A 140(13):1375-1383(2006)
Kano, H., et al. Hum. Genet. 118 (3-4), 477-483 (2005) :
Kang, Y.S., et al. Mol. Cells 17(3):397-403(2004)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Roscioli, T., et al. Am. J. Med. Genet. A 124A (2), 136-141 (2004) :
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