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FBXW4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FBXW4 Antibody (C-term) AP20218B
    FBXW4 Antibody (C-term) (Cat. #AP20218b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the FBXW4 antibody detected the FBXW4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P57775
Other Accession NP_071322.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46337 Da
Antigen Region 341-370 aa
Additional Information
Gene ID 6468
Other Names F-box/WD repeat-containing protein 4, Dactylin, F-box and WD-40 domain-containing protein 4, FBXW4, FBW4, SHFM3
Target/Specificity This FBXW4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the C-terminal region of human FBXW4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXW4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXW4
Synonyms FBW4, SHFM3
Function Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
Tissue Location Expressed in brain, kidney, lung and liver.
Research Areas
Citations (0)

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This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.


Everman, D.B., et al. Am. J. Med. Genet. A 140(13):1375-1383(2006)
Kano, H., et al. Hum. Genet. 118 (3-4), 477-483 (2005) :
Kang, Y.S., et al. Mol. Cells 17(3):397-403(2004)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
Roscioli, T., et al. Am. J. Med. Genet. A 124A (2), 136-141 (2004) :

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$ 295.00
$ 99.00
Cat# AP20218B
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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