|Application ||WB, E|
|Calculated MW||36837 Da|
|Antigen Region||102-128 aa|
|Other Names||Ubiquitin-like domain-containing CTD phosphatase 1, Nuclear proteasome inhibitor UBLCP1, Ublcp1|
|Target/Specificity||This Mouse Ublcp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-128 amino acids from the Central region of mouse Ublcp1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Ublcp1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).|
|Cellular Location||Nucleus. Note=Colocalizes with nuclear proteasomes.|
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Provided below are standard protocols that you may find useful for product applications.
May specifically dephosphorylate 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (By similarity).
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Sasaki, N., et al. Genomics 49(2):167-179(1998)
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