|Application ||WB, E|
|Other Accession||P34975, P33534, NP_000903.2|
|Calculated MW||42645 Da|
|Antigen Region||181-209 aa|
|Other Names||Kappa-type opioid receptor, K-OR-1, KOR-1, OPRK1, OPRK|
|Target/Specificity||This OPRK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the Central region of human OPRK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OPRK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Bruijnzeel, A.W. Brain Res Rev 62(1):127-146(2009)
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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