|Application ||WB, E|
|Calculated MW||23822 Da|
|Antigen Region||171-199 aa|
|Other Names||Guanylyl cyclase-activating protein 3, GCAP 3, Guanylate cyclase activator 1C, GUCA1C, GCAP3|
|Target/Specificity||This GUCA1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human GUCA1C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GUCA1C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.|
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Provided below are standard protocols that you may find useful for product applications.
GUCA1C stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Stephen, R., et al. J. Mol. Biol. 359(2):266-275(2006)
Imanishi, Y., et al. Eur. J. Neurosci. 15(1):63-78(2002)
Haeseleer, F., et al. J. Biol. Chem. 274(10):6526-6535(1999)
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