|Application ||WB, E|
|Other Accession||Q4R5S4, NP_001003803.1|
|Calculated MW||24866 Da|
|Antigen Region||36-64 aa|
|Other Names||ATP synthase subunit s, mitochondrial, ATP synthase-coupling factor B, FB, Mitochondrial ATP synthase regulatory component factor B, ATP5S, ATPW|
|Target/Specificity||This ATP5S antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human ATP5S.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP5S Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway (By similarity).|
|Cellular Location||Mitochondrion. Mitochondrion inner membrane|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified.
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
Cross, R.L. Nature 427(6973):407-408(2004)
Oster, G., et al. Trends Cell Biol. 13(3):114-121(2003)
Leyva, J.A., et al. Mol. Membr. Biol. 20(1):27-33(2003)
Belogrudov, G.I., et al. J. Biol. Chem. 277(8):6097-6103(2002)
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