CMIP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8IY22 |
Other Accession | A1L3F5, Q9D486, NP_085132.1 |
Reactivity | Human |
Predicted | Mouse, Xenopus |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 86331 Da |
Antigen Region | 735-764 aa |
Gene ID | 80790 |
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Other Names | C-Maf-inducing protein, c-Mip, Truncated c-Maf-inducing protein, Tc-Mip, CMIP, KIAA1694, TCMIP |
Target/Specificity | This CMIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-764 amino acids from the C-terminal region of human CMIP. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CMIP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CMIP |
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Synonyms | KIAA1694, TCMIP |
Function | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. |
Cellular Location | Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343) |
Tissue Location | Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
CMIP plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Audard, V., et al. Blood 115(18):3756-3762(2010)
Kamal, M., et al. FEBS Lett. 584(3):500-506(2010)
Zhang, S.Y., et al. Sci Signal 3 (122), RA39 (2010) :
Newbury, D.F., et al. Am. J. Hum. Genet. 85(2):264-272(2009)
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