|Application ||WB, E|
|Other Accession||P62046, NP_055931.1|
|Calculated MW||80875 Da|
|Antigen Region||304-333 aa|
|Other Names||Leucine-rich repeat and calponin homology domain-containing protein 1, Calponin homology domain-containing protein 1, Neuronal protein 81, NP81, LRCH1, CHDC1, KIAA1016|
|Target/Specificity||This LRCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human LRCH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LRCH1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Zintzaras, E., et al. Am. J. Epidemiol. 171(8):851-858(2010)
Jiang, Q., et al. J. Hum. Genet. 53(1):42-47(2008)
Ikegawa, S. Curr Opin Rheumatol 19(5):429-434(2007)
Snelling, S., et al. Rheumatology (Oxford) 46(2):250-252(2007)
Spector, T.D., et al. Arthritis Rheum. 54(2):524-532(2006)
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