|Application ||WB, E|
|Calculated MW||106165 Da|
|Antigen Region||68-96 aa|
|Other Names||Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, ANO6, TMEM16F|
|Target/Specificity||This ANO6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the N-terminal region of human ANO6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANO6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Shows an intracellular localization according to PubMed:22075693|
|Tissue Location||Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer|
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Provided below are standard protocols that you may find useful for product applications.
May act as a calcium-activated chloride channel.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009) :
Katoh, M., et al. Int. J. Oncol. 24(5):1345-1349(2004)
Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :
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