|Application ||WB, E|
|Other Accession||Q05A36, NP_057710.3|
|Calculated MW||69366 Da|
|Antigen Region||536-564 aa|
|Other Names||RNA-binding E3 ubiquitin-protein ligase MEX3C, 632-, RING finger and KH domain-containing protein 2, RING finger protein 194, MEX3C, RKHD2, RNF194|
|Target/Specificity||This MEX3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 536-564 amino acids from the C-terminal region of human MEX3C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MEX3C Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation|
|Tissue Location||Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Buchet-Poyau, K., et al. Nucleic Acids Res. 35(4):1289-1300(2007)
Guzman, B., et al. Hypertension 48(5):883-891(2006)
Nusbaum, C., et al. Nature 437(7058):551-555(2005)
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