|Application ||WB, E|
|Other Accession||Q6DDW4, Q6NVF9, Q6NWC6, Q5ZL34, Q0P5D2, NP_008938.2|
|Predicted||Bovine, Chicken, Zebrafish, Mouse, Xenopus|
|Calculated MW||59210 Da|
|Antigen Region||23-51 aa|
|Other Names||Cleavage and polyadenylation specificity factor subunit 6, Cleavage and polyadenylation specificity factor 68 kDa subunit, CFIm68, CPSF 68 kDa subunit, Pre-mRNA cleavage factor Im 68 kDa subunit, Protein HPBRII-4/7, CPSF6, CFIM68|
|Target/Specificity||This CPSF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-51 amino acids from the N-terminal region of human CPSF6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPSF6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.|
|Cellular Location||Nucleus. Note=In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.
Lee, K., et al. Cell Host Microbe 7(3):221-233(2010)
Ruepp, M.D., et al. Mol. Biol. Cell 20(24):5211-5223(2009)
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Maggi, L.B. Jr., et al. Mol. Cell. Biol. 28(23):7050-7065(2008)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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