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SFXN1 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SFXN1 Antibody (C-term) AP20281b
    SFXN1 Antibody (C-term) (Cat. #AP20281b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SFXN1 antibody detected the SFXN1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H9B4
Other Accession NP_073591.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 35619 Da
Antigen Region 293-321 aa
Additional Information
Gene ID 94081
Other Names Sideroflexin-1, Tricarboxylate carrier protein, TCC, SFXN1
Target/Specificity This SFXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human SFXN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSFXN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFXN1 (HGNC:16085)
Function Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). May also transport other amino acids including alanine and cysteine (PubMed:30442778).
Cellular Location Mitochondrion inner membrane; Multi-pass membrane protein
Tissue Location Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney
Research Areas
Citations (0)
citation

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Background

Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.

References

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Siculella, L., et al. FEBS Lett. 578(3):280-284(2004)
Siculella, L., et al. J. Lipid Res. 45(7):1333-1340(2004)
Giudetti, A.M., et al. J. Lipid Res. 44(11):2135-2141(2003)
Miyake, S., et al. Biochem. Biophys. Res. Commun. 295(2):463-468(2002)

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$ 182.50
$ 70.00
Cat# AP20281b
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