|Application ||WB, E|
|Other Accession||Q811Q0, NP_852006.1|
|Calculated MW||27130 Da|
|Antigen Region||1-30 aa|
|Other Names||Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Hbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, Hbeta3, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2, KCNMB2|
|Target/Specificity||This KCNMB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNMB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNMB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues|
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Provided below are standard protocols that you may find useful for product applications.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene. [provided by RefSeq].
Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)
Lee, U.S., et al. J. Physiol. (Lond.) 587 (PT 7), 1481-1498 (2009) :
Zarei, M.M., et al. Neuroscience 147(1):80-89(2007)
Zeng, X.H., et al. J. Neurosci. 27(17):4707-4715(2007)
Orio, P., et al. J. Gen. Physiol. 127(2):191-204(2006)
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