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RBPMS Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RBPMS Antibody (C-term) AP20354b
    RBPMS Antibody (C-term) (Cat. #AP20354b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RBPMS antibody detected the RBPMS protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q93062
Other Accession Q9WVB0
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21802 Da
Antigen Region 166-193 aa
Additional Information
Gene ID 11030
Other Names RNA-binding protein with multiple splicing, RBP-MS, Heart and RRM expressed sequence, Hermes, RBPMS, HERMES
Target/Specificity This RBPMS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-193 amino acids from the C-terminal region of human RBPMS.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRBPMS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBPMS
Synonyms HERMES
Function Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).
Cellular Location Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress.
Tissue Location Ubiquitously expressed, at various levels depending on the isoform and the tissue
Research Areas
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Background

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

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Cat# AP20354b
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(40 western blots)
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