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TMX1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TMX1 Antibody (C-term) AP20365b
    Anti-TMX1 Antibody (C-term) at 1:1000 dilution + Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 32 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H3N1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 239-267 aa
Additional Information
Other Names Thioredoxin-related transmembrane protein 1, Thioredoxin domain-containing protein 1, Transmembrane Trx-related protein, TMX1, TMX, TXNDC, TXNDC1
Target/Specificity This TMX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human TMX1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTMX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMX1
Synonyms TMX, TXNDC, TXNDC1
Function May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
Cellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein Note=Predominantly found in the endoplasmic reticulum
Tissue Location Ubiquitous. Highly expressed in kidney, liver, placenta and lung EMBL; AB048246; BAB20629.1; -; mRNA EMBL; AY358640; AAQ89003.1; -; mRNA EMBL; AK075395; BAC11593.1; -; mRNA EMBL; AK312905; BAG35751.1; -; mRNA EMBL; AL080080; CAB45700.2; -; mRNA EMBL; AL591807; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471078; EAW65678.1; -; Genomic_DNA EMBL; BC036460; AAH36460.1; -; mRNA EMBL; BC056874; AAH56874.2; -; mRNA CCDS; CCDS41953.1; - PIR; T12471; T12471 RefSeq; NP_110382.3; NM_030755.4 UniGene; Hs.125221; - PDB; 1X5E; NMR; -; A=30-142 PDBsum; 1X5E; - ProteinModelPortal; Q9H3N1; - SMR; Q9H3N1; - BioGrid; 123510; 61 IntAct; Q9H3N1; 37 MINT; Q9H3N1; - STRING; 9606.ENSP00000393316; - iPTMnet; Q9H3N1; - PhosphoSitePlus; Q9H3N1; - SwissPalm; Q9H3N1; - BioMuta; TMX1; - DMDM; 47117631; - EPD; Q9H3N1; - MaxQB; Q9H3N1; - PaxDb; Q9H3N1; - PeptideAtlas; Q9H3N1; - PRIDE; Q9H3N1; - ProteomicsDB; 80733; - TopDownProteomics; Q9H3N1; - DNASU; 81542; - Ensembl; ENST00000457354; ENSP00000393316; ENSG00000139921 GeneID; 81542; - KEGG; hsa:81542; - UCSC; uc001wza.5; human CTD; 81542; - EuPathDB; HostDB:ENSG00000139921.12; - GeneCards; TMX1; - HGNC; HGNC:15487; TMX1 HPA; HPA003085; - MIM; 610527; gene neXtProt; NX_Q9H3N1; - OpenTargets; ENSG00000139921; - PharmGKB; PA37968; - eggNOG; KOG0913; Eukaryota eggNOG; ENOG4111H66; LUCA GeneTree; ENSGT00390000011580; - HOGENOM; HOG000045750; - InParanoid; Q9H3N1; - OMA; CHNYFIE; - OrthoDB; EOG091G0MRE; - PhylomeDB; Q9H3N1; - TreeFam; TF106376; - ChiTaRS; TMX1; human EvolutionaryTrace; Q9H3N1; - GeneWiki; TMX1; - GenomeRNAi; 81542; - PRO; PR:Q9H3N1; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000139921; - CleanEx; HS_TXNDC1; - ExpressionAtlas; Q9H3N1; baseline and differential Genevisible; Q9H3N1; HS GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0015036; F:disulfide oxidoreductase activity; IDA:UniProtKB GO; GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro GO; GO:0006457; P:protein folding; IBA:GO_Central GO; GO:0034976; P:response to endoplasmic reticulum stress; IMP:UniProtKB InterPro; IPR036249; Thioredoxin-like_sf InterPro; IPR017937; Thioredoxin_CS InterPro; IPR013766; Thioredoxin_domain Pfam; PF00085; Thioredoxin; 1 SUPFAM; SSF52833; SSF52833; 1 PROSITE; PS00194; THIOREDOXIN_1; 1 PROSITE; PS51352; THIOREDOXIN_2; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Disulfide bond; Electron transport; Endoplasmic reticulum; Membrane; Phosphoprotein; Redox-active center; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport SIGNAL 1 26 CHAIN 27 280 Thioredoxin-related transmembrane protein 1 /FTId=PRO_0000034153 TOPO_DOM 27 180 Extracellular. TRANSMEM 181 203 Helical. TOPO_DOM 204 280 Cytoplasmic. DOMAIN 27 132 Thioredoxin. {ECO:0000255|PROSITE- ProRule:PRU00691} MOD_RES 228 228 Phosphoserine MOD_RES 247 247 Phosphoserine MOD_RES 270 270 Phosphoserine MOD_RES 274 274 Phosphoserine MOD_RES 280 280 Phosphoserine DISULFID 56 59 Redox-active. {ECO:0000255|PROSITE- ProRule:PRU00691, ECO:0000269|PubMed:11152479} MUTAGEN 56 56 C->S: Loss of reductase activity; when associated with S-59 MUTAGEN 59 59 C->S: Loss of reductase activity; when associated with S-56 CONFLICT 14 16 LVL -> MVP (in Ref. 8; AAH36460) CONFLICT 98 98 T -> N (in Ref. 8; AAH36460) CONFLICT 177 177 V -> A (in Ref. 4; BAC11593) STRAND 30 33 {ECO:0000244|PDB:1X5E} TURN 36 38 {ECO:0000244|PDB:1X5E} HELIX 39 42 {ECO:0000244|PDB:1X5E} STRAND 44 52 {ECO:0000244|PDB:1X5E} HELIX 57 73 {ECO:0000244|PDB:1X5E} HELIX 74 76 {ECO:0000244|PDB:1X5E} STRAND 79 84 {ECO:0000244|PDB:1X5E} TURN 85 87 {ECO:0000244|PDB:1X5E} HELIX 89 94 {ECO:0000244|PDB:1X5E} STRAND 99 107 {ECO:0000244|PDB:1X5E} STRAND 110 113 {ECO:0000244|PDB:1X5E} HELIX 120 128 {ECO:0000244|PDB:1X5E} HELIX 131 134 {ECO:0000244|PDB:1X5E} SEQUENCE 280 AA; 31791 MW; A57E222481A997DE CRC64; MAPSGSLAVP LAVLVLLLWG APWTHGRRSN VRVITDENWR ELLEGDWMIE FYAPWCPACQ NLQPEWESFA EWGEDLEVNI AKVDVTEQPG LSGRFIITAL PTIYHCKDGE FRRYQGPRTK KDFINFISDK EWKSIEPVSS WFGPGSVLMS SMSALFQLSM WIRTCHNYFI EDLGLPVWGS YTVFALATLF SGLLLGLCMI FVADCLCPSK RRRPQPYPYP SKKLLSESAQ PLKKVEEEQE ADEEDVSEEE AESKEGTNKD FPQNAIRQRS LGPSLATDKS
Research Areas
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Background

May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.

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$ 295.00
$ 99.00
Cat# AP20365b
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(40 western blots)
Availability: In Stock
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