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L3MBTL3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96JM7 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 88337 Da |
| Antigen Region | 90-116 aa |
| Gene ID | 84456 |
|---|---|
| Other Names | Lethal(3)malignant brain tumor-like protein 3, H-l(3)mbt-like protein 3, L(3)mbt-like protein 3, MBT-1, L3MBTL3, KIAA1798, MBT1 |
| Target/Specificity | This L3MBTL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-116 amino acids from the N-terminal region of human L3MBTL3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | L3MBTL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | L3MBTL3 (HGNC:23035) |
|---|---|
| Synonyms | KIAA1798, MBT1 |
| Function | Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713, PubMed:29691401). Required for normal maturation of myeloid progenitor cells (By similarity). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
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