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ICT1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IHC-P - ICT1 Antibody (C-term) AP20382b
    Immunohistochemical analysis of paraffin-embedded H. colorectal carcinoma section using ICT1 Antibody (C-term)(Cat#AP20382b). AP20382b was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
  • IHC-P - ICT1 Antibody (C-term) AP20382b
    Immunohistochemical analysis of paraffin-embedded H. skin section using ICT1 Antibody (C-term)(Cat#AP20382b). AP20382b was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
  • WB - ICT1 Antibody (C-term) AP20382b
    ICT1 Antibody (C-term) (Cat. #AP20382b) western blot analysis in Hela,Jurkat,U251,MDA-MB453,NCI-H292,K562,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ICT1 antibody detected the ICT1 protein (arrow).
  • SPECIFICATION
  • CITATIONS: 4
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14197
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23630 Da
Antigen Region 153-179 aa
Additional Information
Gene ID 3396
Other Names Peptidyl-tRNA hydrolase ICT1, mitochondrial, 39S ribosomal protein L58, mitochondrial, MRP-L58, Digestion substraction 1, DS-1, Immature colon carcinoma transcript 1 protein, ICT1, DS1
Target/Specificity This ICT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-179 amino acids from the C-terminal region of human ICT1.
Dilution IHC-P~~1:25
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsICT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRPL58 (HGNC:5359)
Synonyms DS1, ICT1
Function Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
Cellular Location Mitochondrion
Tissue Location Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells
Research Areas
Citations ( 0 )

Background

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

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$ 295.00
$ 99.00
Cat# AP20382b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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