|Application ||WB, IHC-P, IF, E|
|Other Accession||P19332, P10637, P29172|
|Reactivity||Human, Mouse, Rat, Cynomolgus Monkey|
|Calculated MW||78928 Da|
|Antigen Region||677-707 aa|
|Other Names||Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU|
|Target/Specificity||This TAU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 amino acids from the C-terminal region of human TAU.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAU Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||MAPTL, MTBT1, TAU|
|Function||Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.|
|Cellular Location||Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components|
|Tissue Location||Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system|
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Provided below are standard protocols that you may find useful for product applications.
The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Yoshiyama, Y., et al., J. Neurosci. 23(33):10662-10671 (2003).
Horiguchi, T., et al., Am. J. Pathol. 163(3):1021-1031 (2003).
Gamblin, T.C., et al., Proc. Natl. Acad. Sci. U.S.A. 100(17):10032-10037 (2003).
Kraemer, B.C., et al., Proc. Natl. Acad. Sci. U.S.A. 100(17):9980-9985 (2003).
Yancopoulou, D., et al., J. Neuropathol. Exp. Neurol. 62(8):878-882 (2003).
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