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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VEGFC (VEGF3) Antibody (Center M263)   

VEGFC (VEGF3) Antibody (Center M263)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - VEGFC (VEGF3) Antibody (Center M263) AP2042C
    Western blot analysis of VEGF3 Antibody (Center) polyclonal antibody(Cat.#AP2042c)(arrow). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the VEGF3 gene (Lane 2) (Origene Technologies).
  • IHC-P - VEGFC (VEGF3) Antibody (Center M263) AP2042C
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with VEGF3 Antibody (Center M263)(Cat.#AP2042c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P49767
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46883 Da
Antigen Region 248-277 aa
Additional Information
Gene ID 7424
Other Names Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP, VEGFC
Target/Specificity This VEGFC (VEGF3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-277 amino acids from the Central region of human VEGFC (VEGF3).
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVEGFC (VEGF3) Antibody (Center M263) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VEGFC
Function Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Cellular Location Secreted.
Tissue Location Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte
Research Areas
Citations (0)

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Background

VEGF3 is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

References

Byeon, J.S., et al., J. Gastroenterol. Hepatol. 19(6):648-654 (2004).
Su, J.L., et al., Cancer Res. 64(2):554-564 (2004).
Yan, C., et al., World J. Gastroenterol. 10(6):783-790 (2004).
Hsieh, C.Y., et al., J. Biomed. Sci. 11(2):249-259 (2004).
Liu, X.E., et al., World J. Gastroenterol. 10(3):352-355 (2004).

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Cat# AP2042C
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(40 western blots)
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