|Application ||WB, IHC-P, E|
|Calculated MW||46883 Da|
|Antigen Region||248-277 aa|
|Other Names||Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP, VEGFC|
|Target/Specificity||This VEGFC (VEGF3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-277 amino acids from the Central region of human VEGFC (VEGF3).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VEGFC (VEGF3) Antibody (Center M263) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.|
|Tissue Location||Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte|
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Provided below are standard protocols that you may find useful for product applications.
VEGF3 is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
Byeon, J.S., et al., J. Gastroenterol. Hepatol. 19(6):648-654 (2004).
Su, J.L., et al., Cancer Res. 64(2):554-564 (2004).
Yan, C., et al., World J. Gastroenterol. 10(6):783-790 (2004).
Hsieh, C.Y., et al., J. Biomed. Sci. 11(2):249-259 (2004).
Liu, X.E., et al., World J. Gastroenterol. 10(3):352-355 (2004).
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