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VEGFC (VEGF3) Antibody (Center M263)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP2042c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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VEGFC (VEGF3) Antibody (Center M263) - Product info | |
| Application | WB, IHC
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| Primary Accession | P49767 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 46883 Da |
VEGFC (VEGF3) Antibody (Center M263) - Additional info | |
| Gene ID 7424 | |
| Other Names VEGFC; Vascular endothelial growth factor C; Flt4 ligand; Vascular endothelial growth factor-related protein | |
| Target/Specificity This VEGFC (VEGF3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255~285 amino acids from the center region of human VEGF3. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions VEGFC (VEGF3) Antibody (Center M263) is for research use only and not for use in diagnostic or therapeutic procedures. | |
VEGFC (VEGF3) Antibody (Center M263) - Protein Information | |
| Name VEGFC | |
| Function Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors | |
| Cellular Location Secreted. | |
| Tissue Location Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte | |
VEGFC (VEGF3) Antibody (Center M263) - Related products
AM1886a: VEGFC antibody ( Ascites)
AP11951a: VEGF3 Antibody (N-term)
AP2042c: VEGFC (VEGF3) Antibody (Center M263)
RI15683: VEGFC predesign siRNA
DC06850: Human VEGFC cDNA Clone
VEGFC (VEGF3) Antibody (Center M263) - Application data
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Western blot analysis of VEGF3 Antibody (Center) polyclonal antibody(Cat.#AP2042c)(arrow). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the VEGF3 gene (Lane 2) (Origene Technologies).
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Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with VEGF3 Antibody (Center M263)(Cat.#AP2042c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
VEGFC (VEGF3) Antibody (Center M263) - Research Areas
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BACKGROUND
VEGF3 is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
REFERENCES
Byeon, J.S., et al., J. Gastroenterol. Hepatol. 19(6):648-654 (2004). Su, J.L., et al., Cancer Res. 64(2):554-564 (2004). Yan, C., et al., World J. Gastroenterol. 10(6):783-790 (2004). Hsieh, C.Y., et al., J. Biomed. Sci. 11(2):249-259 (2004). Liu, X.E., et al., World J. Gastroenterol. 10(3):352-355 (2004).
