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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VEGFC Antibody   

VEGFC Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • FC - VEGFC Antibody AP2042d
    Overlay histogram showing HepG2 cells stained with AP2042d(green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (AP2042d, 1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight® 488 Conjugated Highly Cross-Adsorbed(OH191631) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG1 (1μg/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • WB - VEGFC Antibody AP2042d
    All lanes : Anti-VEGFC Antibody at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: CCRF-CEM whole cell lysate Lane 3: K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - VEGFC Antibody AP2042d
    All lanes : Anti-VEGFC Antibody at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: K562 whole cell lysate Lane 3: HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • SPECIFICATION
  • CITATIONS: 5
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession P49767
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46883 Da
Additional Information
Gene ID 7424
Other Names Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular endothelial growth factor-related protein, VRP, VEGFC
Target/Specificity This VEGFC antibody is generated from rabbits immunized with VEGFC recombinant protein.
Dilution FC~~1:25
WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVEGFC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VEGFC
Function Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Cellular Location Secreted.
Tissue Location Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte
Research Areas
Citations ( 0 )

Background

VEGF3 is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

References

Byeon, J.S., et al., J. Gastroenterol. Hepatol. 19(6):648-654 (2004). Su, J.L., et al., Cancer Res. 64(2):554-564 (2004). Yan, C., et al., World J. Gastroenterol. 10(6):783-790 (2004). Hsieh, C.Y., et al., J. Biomed. Sci. 11(2):249-259 (2004). Liu, X.E., et al., World J. Gastroenterol. 10(3):352-355 (2004).

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$ 295.00
$ 99.00
Cat# AP2042d
Size:
Quantity:
(40 western blots)
Availability: In Stock
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