|Application ||WB, IF, IHC-P, E|
|Other Accession||P62193, P62192|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||49185 Da|
|Antigen Region||408-436 aa|
|Other Names||26S protease regulatory subunit 4, P26s4, 26S proteasome AAA-ATPase subunit RPT2, Proteasome 26S subunit ATPase 1, PSMC1|
|Target/Specificity||This PRS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of human PRS4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRS4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Dubiel W., et al. J. Biol. Chem. 267:22699-22702(1992).
Ebert L., et al. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Matilla A., et al. Hum. Mol. Genet. 10:2821-2831(2001).
Brill L.M., et al. Anal. Chem. 76:2763-2772(2004).
Katiyar S., et al. Proc. Natl. Acad. Sci. U.S.A. 101:13774-13779(2004).
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