|Application ||WB, IHC-P, E|
|Calculated MW||63544 Da|
|Antigen Region||563-591 aa|
|Other Names||Granulins, Proepithelin, PEPI, Acrogranin, Glycoprotein of 88 Kda, Progranulin, Paragranulin, Granulin-1, Granulin G, Granulin-2, Granulin F, Granulin-3, Granulin B, Granulin-4, Granulin A, Granulin-5, Granulin C, Granulin-6, Granulin D, Granulin-7, Granulin E, GRN|
|Target/Specificity||This GRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 563-591 amino acids from the C-terminal region of human GRN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.|
|Tissue Location||In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney|
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Provided below are standard protocols that you may find useful for product applications.
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.
Bhandari V., et al. Biochem. Biophys. Res. Commun. 188:57-63(1992).
Plowman G.D., et al. J. Biol. Chem. 267:13073-13078(1992).
Bhandari V., et al. Proc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992).
Lu R., et al. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Yu W., et al. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
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