|Application ||WB, E|
|Calculated MW||79435 Da|
|Antigen Region||380-409 aa|
|Other Names||Testis-specific Y-encoded-like protein 2, TSPY-like protein 2, Cell division autoantigen 1, Cutaneous T-cell lymphoma-associated antigen se20-4, CTCL-associated antigen se20-4, Differentially-expressed nucleolar TGF-beta1 target protein, Nuclear protein of 79 kDa, NP79, TSPYL2, CDA1, DENTT, TSPX|
|Target/Specificity||This TSPYL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human TSPYL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TSPYL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CDA1, DENTT, TSPX|
|Function||Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.|
|Cellular Location||Nucleus. Cytoplasm Note=Enriched in transcriptionally active regions of chromatin in neurons.|
|Tissue Location||Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Dephoure N., et al. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Chai Z., et al. J. Biol. Chem. 276:33665-33674(2001).
Eichmueller S., et al. Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
Bechtel S., et al. BMC Genomics 8:399-399(2007).
Ross M.T., et al. Nature 434:325-337(2005).
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