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NTN1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - NTN1 Antibody (C-term) AP20462b
    NTN1 Antibody (C-term) (Cat. #AP20462b) western blot analysis in U87-MG cell line lysates (35ug/lane).This demonstrates the NTN1 antibody detected the NTN1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O95631
Other Accession Q2HXW4, O09118, Q90922
Reactivity Human
Predicted Chicken, Mouse, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 568-596 aa
Additional Information
Other Names Netrin-1, Epididymis tissue protein Li 131P, NTN1, NTN1L
Target/Specificity This NTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 568-596 amino acids from the C-terminal region of human NTN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNTN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NTN1
Synonyms NTN1L
Function Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas Expressed in epididymis (at protein level) EMBL; U75586; AAD09221.1; -; mRNA EMBL; GU727649; ADU87650.1; -; mRNA EMBL; AC090610; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AC005695; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS11148.1; - RefSeq; NP_004813.2; NM_004822.2 RefSeq; XP_006721658.1; XM_006721595.3 UniGene; Hs.660885; - PDB; 4URT; X-ray; 3.10 A; A=39-453 PDB; 6FKQ; X-ray; 3.07 A; A=39-453 PDBsum; 4URT; - PDBsum; 6FKQ; - ProteinModelPortal; O95631; - SMR; O95631; - BioGrid; 114816; 6 DIP; DIP-46273N; - IntAct; O95631; 7 STRING; 9606.ENSP00000173229; - iPTMnet; O95631; - PhosphoSitePlus; O95631; - BioMuta; NTN1; - MaxQB; O95631; - PaxDb; O95631; - PeptideAtlas; O95631; - PRIDE; O95631; - ProteomicsDB; 50967; - Ensembl; ENST00000173229; ENSP00000173229; ENSG00000065320 GeneID; 9423; - KEGG; hsa:9423; - UCSC; uc002glw.4; human CTD; 9423; - DisGeNET; 9423; - EuPathDB; HostDB:ENSG00000065320.8; - GeneCards; NTN1; - H-InvDB; HIX0039241; - HGNC; HGNC:8029; NTN1 HPA; HPA056419; - MalaCards; NTN1; - MIM; 601614; gene neXtProt; NX_O95631; - OpenTargets; ENSG00000065320; - PharmGKB; PA31813; - eggNOG; KOG3512; Eukaryota eggNOG; ENOG410XS7U; LUCA GeneTree; ENSGT00890000139348; - HOGENOM; HOG000286017; - HOVERGEN; HBG006464; - InParanoid; O95631; - KO; K06843; - OMA; DQFLWVR; - OrthoDB; EOG091G005L; - PhylomeDB; O95631; - TreeFam; TF352481; - Reactome; R-HSA-373752; Netrin-1 signaling Reactome; R-HSA-376172; DSCAM interactions Reactome; R-HSA-418885; DCC mediated attractive signaling Reactome; R-HSA-418886; Netrin mediated repulsion signals Reactome; R-HSA-418890; Role of second messengers in netrin-1 signaling Reactome; R-HSA-428542; Regulation of commissural axon pathfinding by SLIT and ROBO SIGNOR; O95631; - ChiTaRS; NTN1; human GeneWiki; NTN1; - GenomeRNAi; 9423; - PRO; PR:O95631; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000065320; - CleanEx; HS_NTN1; - ExpressionAtlas; O95631; baseline and differential Genevisible; O95631; HS GO; GO:0005604; C:basement membrane; IEA:Ensembl GO; GO:0005737; C:cytoplasm; IEA:Ensembl GO; GO:0005576; C:extracellular region; TAS:Reactome GO; GO:0033564; P:anterior/posterior axon guidance; IEA:Ensembl GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO; GO:0007411; P:axon guidance; TAS:Reactome GO; GO:0032488; P:Cdc42 protein signal transduction; ISS:UniProtKB GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl GO; GO:0060603; P:mammary gland duct morphogenesis; IEA:Ensembl GO; GO:0030517; P:negative regulation of axon extension; IEA:Ensembl GO; GO:0001764; P:neuron migration; IEA:Ensembl GO; GO:0007097; P:nuclear migration; IEA:Ensembl GO; GO:0045773; P:positive regulation of axon extension; ISS:UniProtKB GO; GO:2000147; P:positive regulation of cell motility; ISS:UniProtKB GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl GO; GO:0007265; P:Ras protein signal transduction; ISS:UniProtKB GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl GO; GO:0006930; P:substrate-dependent cell migration, cell extension; ISS:UniProtKB Gene3D; 2.60.120.1490; -; 1 InterPro; IPR008979; Galactose-bd-like_sf InterPro; IPR002049; Laminin_EGF InterPro; IPR008211; Laminin_N InterPro; IPR038684; Laminin_N_sf InterPro; IPR001134; Netrin_domain InterPro; IPR018933; Netrin_module_non-TIMP InterPro; IPR008993; TIMP-like_OB-fold Pfam; PF00053; Laminin_EGF; 3 Pfam; PF00055; Laminin_N; 1 Pfam; PF01759; NTR; 1 SMART; SM00643; C345C; 1 SMART; SM00180; EGF_Lam; 3 SMART; SM00136; LamNT; 1 SUPFAM; SSF49785; SSF49785; 1 SUPFAM; SSF50242; SSF50242; 1 PROSITE; PS00022; EGF_1; 2 PROSITE; PS01248; EGF_LAM_1; 3 PROSITE; PS50027; EGF_LAM_2; 3 PROSITE; PS51117; LAMININ_NTER; 1 PROSITE; PS50189; NTR; 1 1: Evidence at protein level; 3D-structure; Apoptosis; Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Laminin EGF-like domain; Polymorphism; Reference proteome; Repeat; Secreted; Signal SIGNAL 1 24 CHAIN 25 604 Netrin-1 /FTId=PRO_0000017082 DOMAIN 47 284 Laminin N-terminal. {ECO:0000255|PROSITE- ProRule:PRU00466} DOMAIN 285 340 Laminin EGF-like 1. {ECO:0000255|PROSITE- ProRule:PRU00460} DOMAIN 341 403 Laminin EGF-like 2. {ECO:0000255|PROSITE- ProRule:PRU00460} DOMAIN 404 453 Laminin EGF-like 3. {ECO:0000255|PROSITE- ProRule:PRU00460} DOMAIN 472 601 NTR. {ECO:0000255|PROSITE- ProRule:PRU00295} MOTIF 530 532 Cell attachment site. CARBOHYD 95 95 N-linked (GlcNAc...) asparagine CARBOHYD 116 116 N-linked (GlcNAc...) asparagine CARBOHYD 131 131 N-linked (GlcNAc...) asparagine CARBOHYD 417 417 N-linked (GlcNAc...) asparagine DISULFID 119 152 DISULFID 285 294 DISULFID 287 304 DISULFID 306 315 DISULFID 318 338 DISULFID 341 350 DISULFID 343 368 DISULFID 371 380 DISULFID 383 401 DISULFID 404 416 DISULFID 406 423 DISULFID 425 434 DISULFID 437 451 DISULFID 472 544 DISULFID 491 601 VARIANT 351 351 R -> H (in a neuroblastoma sample; dbSNP:rs531668666) /FTId=VAR_014279 VARIANT 489 489 K -> E (in a neuroblastoma sample) /FTId=VAR_014280 CONFLICT 299 299 D -> T (in Ref. 1; AAD09221) STRAND 44 46 {ECO:0000244|PDB:6FKQ} TURN 58 61 {ECO:0000244|PDB:6FKQ} STRAND 65 67 {ECO:0000244|PDB:6FKQ} STRAND 75 83 {ECO:0000244|PDB:6FKQ} STRAND 86 94 {ECO:0000244|PDB:6FKQ} HELIX 99 101 {ECO:0000244|PDB:6FKQ} HELIX 106 109 {ECO:0000244|PDB:6FKQ} STRAND 132 153 {ECO:0000244|PDB:6FKQ} STRAND 156 166 {ECO:0000244|PDB:6FKQ} STRAND 172 179 {ECO:0000244|PDB:6FKQ} HELIX 181 185 {ECO:0000244|PDB:6FKQ} HELIX 197 199 {ECO:0000244|PDB:4URT} STRAND 202 204 {ECO:0000244|PDB:4URT} STRAND 212 215 {ECO:0000244|PDB:6FKQ} STRAND 217 221 {ECO:0000244|PDB:6FKQ} TURN 222 225 {ECO:0000244|PDB:4URT} HELIX 232 234 {ECO:0000244|PDB:6FKQ} HELIX 236 241 {ECO:0000244|PDB:6FKQ} STRAND 243 254 {ECO:0000244|PDB:6FKQ} STRAND 257 259 {ECO:0000244|PDB:4URT} HELIX 265 269 {ECO:0000244|PDB:6FKQ} STRAND 275 285 {ECO:0000244|PDB:6FKQ} STRAND 292 296 {ECO:0000244|PDB:6FKQ} STRAND 302 305 {ECO:0000244|PDB:6FKQ} STRAND 310 312 {ECO:0000244|PDB:6FKQ} TURN 344 346 {ECO:0000244|PDB:6FKQ} STRAND 350 352 {ECO:0000244|PDB:6FKQ} HELIX 354 359 {ECO:0000244|PDB:6FKQ} STRAND 366 368 {ECO:0000244|PDB:6FKQ} TURN 372 374 {ECO:0000244|PDB:6FKQ} STRAND 375 380 {ECO:0000244|PDB:6FKQ} STRAND 387 389 {ECO:0000244|PDB:6FKQ} STRAND 391 393 {ECO:0000244|PDB:6FKQ} STRAND 401 403 {ECO:0000244|PDB:6FKQ} TURN 408 410 {ECO:0000244|PDB:6FKQ} TURN 418 420 {ECO:0000244|PDB:6FKQ} TURN 431 434 {ECO:0000244|PDB:6FKQ} STRAND 447 449 {ECO:0000244|PDB:6FKQ} STRAND 451 453 {ECO:0000244|PDB:4URT} SEQUENCE 604 AA; 67748 MW; 9827C09D0D783B27 CRC64; MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNASDPK KAHPPAFLTD LNNPHNLTCW QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD WVTATDIRVA FSRLHTFGDE NEDDSELARD SYFYAVSDLQ VGGRCKCNGH AARCVRDRDD SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS GRKSGGVCLN CRHNTAGRHC HYCKEGYYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSVEEPE DCDSYCKASK GKLKINMKKY CKKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK CKKA
Research Areas
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Background

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

References

Meyerhardt J.A., et al. Cell Growth Differ. 10:35-42(1999).
Zody M.C., et al. Nature 440:1045-1049(2006).
Li J., et al. Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L., et al. Nature 431:80-84(2004).
Liu G., et al. Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).

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$ 295.00
$ 99.00
Cat# AP20462b
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(40 western blots)
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