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R Cask Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - R Cask Antibody (Center) AP20487c
    Rat Cask Antibody (Center) (Cat. #AP20487c) western blot analysis in rat brain tissue lysates (35ug/lane).This demonstrates the Rat Cask antibody detected the Rat Cask protein (arrow).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q62915
Other Accession O70589, O14936
Reactivity Rat
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 103259 Da
Antigen Region 589-616 aa
Additional Information
Gene ID 29647
Other Names Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase, Cask
Target/Specificity This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsR Cask Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cask
Function Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Cellular Location Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein
Tissue Location Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). Detected in brain and neurons
Research Areas
Citations (0)

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Background

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

References

Hata Y., et al. J. Neurosci. 16:2488-2494(1996).
Butz S., et al. Cell 94:773-782(1998).
Hsueh Y.P., et al. Nature 404:298-302(2000).
Tabuchi K., et al. J. Neurosci. 22:4264-4273(2002).
Chetkovich D.M., et al. J. Neurosci. 22:6415-6425(2002).

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$ 295.00
$ 99.00
Cat# AP20487c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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