|Application ||WB, E|
|Calculated MW||67209 Da|
|Antigen Region||192-220 aa|
|Other Names||Interferon-induced guanylate-binding protein 2, GTP-binding protein 2, GBP-2, HuGBP-2, Guanine nucleotide-binding protein 2, GBP2|
|Target/Specificity||This GBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the Central region of human GBP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GBP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).|
|Cellular Location||Cytoplasm. Nucleus. Golgi apparatus membrane; Lipid-anchor|
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Provided below are standard protocols that you may find useful for product applications.
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product.
Cheng Y.-S.E., et al. Mol. Cell. Biol. 11:4717-4725(1991).
Schwemmle M., et al. Submitted (SEP-1991) to the EMBL/GenBank/DDBJ databases.
Bechtel S., et al. BMC Genomics 8:399-399(2007).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Ebert L., et al. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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