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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SOX2 Antibody (N-term)   

SOX2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SOX2 Antibody (N-term) AP2048D
    Western blot analysis of SOX2 Antibody (N-term) in 293 cell line lysates (35ug/lane). SOX2(arrow) was detected using the purified Pab.
  • WB - SOX2 Antibody (N-term) AP2048D
    Western blot analysis of SOX2 (arrow) using rabbit polyclonal SOX2 Antibody (N-term) (Cat.#AP2048d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SOX2 gene (Lane 2) (Origene Technologies).
  • IHC-P - SOX2 Antibody (N-term) AP2048D
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SOX2 antibody (N-term) (Cat.#AP2048d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • IF - SOX2 Antibody (N-term) AP2048D
    Immunofluorescence analysis of SOX2 Antibody (N-term) (Cat.#AP2048d) in HeLa cells. 0.025 mg/ml primary antibody was followed by Alexa-Fluor-546-conjugated donkey anti-rabbit lgG (H+L). Alexa-Fluor-546 emits orange fluorescence. Blue counterstaining is DAPI.
  • FC - SOX2 Antibody (N-term) AP2048D
    Flow cytometric analysis of NCI-H292 cells using SOX2 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48431
Other Accession Q6EJB7, O42569, P48432, Q6P0E1, P48430, Q2PG84, P53783, O00570, O57401, Q2Z1R2, Q6DGL6, P54231
Reactivity Human
Predicted Zebrafish, Chicken, Mouse, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 34310 Da
Antigen Region 89-119 aa
Additional Information
Gene ID 6657
Other Names Transcription factor SOX-2, SOX2
Target/Specificity This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-119 amino acids from the N-terminal region of human SOX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX2
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus.
Research Areas
Citations ( 0 )


The intronless gene for SOX2 encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.


Remenyi, A., et al., Genes Dev. 17(16):2048-2059 (2003).
Wiebe, M.S., et al., J. Biol. Chem. 278(20):17901-17911 (2003).
Fantes, J., et al., Nat. Genet. 33(4):461-463 (2003).
Schepers, G.E., et al., Dev. Cell 3(2):167-170 (2002).
Kamachi, Y., et al., Trends Genet. 16(4):182-187 (2000).

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$ 295.00
$ 99.00
Cat# AP2048D
(40 western blots)
Availability: In Stock
Bulk Size
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