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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SOX2 Antibody   

SOX2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SOX2 Antibody AP2048f
    Anti-SOX2 Antibody at 1:1000 dilution + NCCIT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SOX2 Antibody AP2048f
    Western blot analysis of SOX2 (arrow) using rabbit polyclonal SOX2 Antibody (Cat.#AP2048f). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SOX2 gene (Lane 2) (Origene Technologies).
  • FC - SOX2 Antibody AP2048f
    SOX2 Antibody (Cat. #AP2048f) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48431
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 34310 Da
Additional Information
Gene ID 6657
Other Names Transcription factor SOX-2, SOX2
Target/Specificity This SOX2 antibody is generated from rabbits immunized with a recombinant protein of human SOX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX2
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.


Remenyi, A., et al., Genes Dev. 17(16):2048-2059 (2003).
Wiebe, M.S., et al., J. Biol. Chem. 278(20):17901-17911 (2003).
Fantes, J., et al., Nat. Genet. 33(4):461-463 (2003).
Schepers, G.E., et al., Dev. Cell 3(2):167-170 (2002).
Kamachi, Y., et al., Trends Genet. 16(4):182-187 (2000).

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$ 295.00
$ 99.00
Cat# AP2048f
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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