|Application ||WB, IHC-P, E|
|Calculated MW||27992 Da|
|Antigen Region||120-147 aa|
|Other Names||B-cell receptor-associated protein 31, BCR-associated protein 31, Bap31, 6C6-AG tumor-associated antigen, Protein CDM, p28, BCAP31, BAP31, DXS1357E|
|Target/Specificity||This BCAP31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-147 amino acids from the Central region of human BCAP31.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BCAP31 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8- mediated apoptosis.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex|
|Tissue Location||Ubiquitous. Highly expressed in neurons and discrete endocrine cells.|
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Provided below are standard protocols that you may find useful for product applications.
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.
Mosser J., et al. Genomics 22:469-471(1994).
Li E., et al. Eur. J. Biochem. 238:631-638(1996).
Adachi T., et al. EMBO J. 15:1534-1541(1996).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Ross M.T., et al. Nature 434:325-337(2005).
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