|Application ||WB, E|
|Calculated MW||43747 Da|
|Antigen Region||330-361 aa|
|Other Names||Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, CD46, MCP, MIC10|
|Target/Specificity||This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD46 Antibody (Center Y354) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single- pass type I membrane protein Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide|
|Tissue Location||Expressed by all cells except erythrocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Riley R.C., et al. Mol. Reprod. Dev. 62:534-546(2002).
Lublin D.M., et al. J. Exp. Med. 168:181-194(1988).
Purcell D.F., et al. Immunogenetics 33:335-344(1991).
Post T.W., et al. J. Exp. Med. 174:93-102(1991).
Cervoni F., et al. Mol. Reprod. Dev. 34:107-113(1993).
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