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M Gpr68 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - M Gpr68 Antibody (Center) AP20524c
    Mouse Gpr68 Antibody (Center) (Cat. #AP20524c) western blot analysis in mouse liver and heart tissue lysates (35ug/lane).This demonstrates the Mouse Gpr68 antibody detected the Mouse Gpr68 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8BFQ3
Other Accession Q15743, O46685
Reactivity Mouse
Predicted Bovine, Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41209 Da
Antigen Region 200-225 aa
Additional Information
Gene ID 238377
Other Names Ovarian cancer G-protein coupled receptor 1, G-protein coupled receptor 68, Sphingosylphosphorylcholine receptor, Gpr68, Ogr1
Target/Specificity This Mouse Gpr68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-225 amino acids from the Central region of mouse Gpr68.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsM Gpr68 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Gpr68
Synonyms Ogr1
Function Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable.
Research Areas
Citations (0)

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Background

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.

References

Carninci P., et al. Science 309:1559-1563(2005).
Vassilatis D.K., et al. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
Singh L.S., et al. J. Natl. Cancer Inst. 99:1313-1327(2007).
Frick K.K., et al. J. Bone Miner. Res. 24:305-313(2009).
Li H., et al. PLoS ONE 4:E5705-E5705(2009).

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$ 295.00
$ 99.00
Cat# AP20524c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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