|Application ||WB, E|
|Calculated MW||48487 Da|
|Antigen Region||377-401 aa|
|Other Names||Keratin, type I cytoskeletal 20, Cytokeratin-20, CK-20, Keratin-20, K20, Protein IT, KRT20|
|Target/Specificity||This KRT20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-401 amino acids from the C-terminal region of human KRT20.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KRT20 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).|
|Tissue Location||Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.|
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Provided below are standard protocols that you may find useful for product applications.
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).
Moll R., et al. Differentiation 53:75-93(1993).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Zhou Q., et al. J. Biol. Chem. 281:16453-16461(2006).
Calnek D., et al. Differentiation 53:95-104(1993).
Moll R., et al. J. Cell Biol. 111:567-580(1990).
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