|Application ||WB, FC, E|
|Calculated MW||13460 Da|
|Other Names||T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, TCL1A, TCL1|
|Target/Specificity||This TCL1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the Central region of human TCL1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCL1A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.|
|Cellular Location||Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction|
|Tissue Location||Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation|
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Provided below are standard protocols that you may find useful for product applications.
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Virgilio L.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:12530-12534(1994).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Fu T.-B.,et al.Cancer Res. 54:6297-6301(1994).
Laine J.,et al.Mol. Cell 6:395-407(2000).
Pekarsky Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:3028-3033(2000).
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