|Application ||WB, E|
|Calculated MW||26216 Da|
|Other Names||Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, FcR-10, IgG Fc receptor III-1, CD16b, FCGR3B, CD16B, FCG3, FCGR3, IGFR3|
|Target/Specificity||This FCGR3B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-47 amino acids from the N-terminal region of human FCGR3B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCGR3B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD16B, FCG3, FCGR3, IGFR3|
|Function||Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage|
|Tissue Location||Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Ravetch J.V.,et al.J. Exp. Med. 170:481-497(1989).
Simmons D.,et al.Nature 333:568-570(1988).
Simmons D.,et al.Nature 340:662-662(1989).
Peltz G.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:1013-1017(1989).
Scallon B.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:5079-5083(1989).
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