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FCGR3B Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O75015 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26243 Da |
| Antigen Region | 12-47 aa |
| Gene ID | 2215 |
|---|---|
| Other Names | Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, FcR-10, IgG Fc receptor III-1, CD16b, FCGR3B, CD16B, FCG3, FCGR3, IGFR3 |
| Target/Specificity | This FCGR3B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-47 amino acids from the N-terminal region of human FCGR3B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FCGR3B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCGR3B |
|---|---|
| Synonyms | CD16B, FCG3, FCGR3, IGFR3 |
| Function | Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted Note=Secreted after cleavage |
| Tissue Location | Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
References
Ravetch J.V.,et al.J. Exp. Med. 170:481-497(1989).
Simmons D.,et al.Nature 333:568-570(1988).
Simmons D.,et al.Nature 340:662-662(1989).
Peltz G.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:1013-1017(1989).
Scallon B.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:5079-5083(1989).
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