|Application ||WB, IHC-P, E|
|Calculated MW||53122 Da|
|Antigen Region||33-62 aa|
|Other Names||Bone morphogenetic protein 3B, BMP-3B, Bone-inducing protein, BIP, Growth/differentiation factor 10, GDF-10, GDF10, BMP3B|
|Target/Specificity||This GDF10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human GDF10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GDF10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.|
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Provided below are standard protocols that you may find useful for product applications.
GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.
Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).
Hino, J., et al., Biochem. Biophys. Res. Commun. 223(2):304-310 (1996).
Cunningham, N.S., et al., Growth Factors 12(2):99-109 (1995).
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