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GDF10 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GDF10 Antibody (N-term) AP2060a
    Western blot analysis of anti-GDF10 Antibody (N-term) (Cat.#AP2060a) in 293 cell line lysates (35ug/lane). GDF10 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - GDF10 Antibody (N-term) AP2060a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P55107
Other Accession NP_004953
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 53122 Da
Antigen Region 33-62 aa
Additional Information
Gene ID 2662
Other Names Bone morphogenetic protein 3B, BMP-3B, Bone-inducing protein, BIP, Growth/differentiation factor 10, GDF-10, GDF10, BMP3B
Target/Specificity This GDF10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human GDF10.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGDF10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF10 (HGNC:4215)
Synonyms BMP3B
Function Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Cellular Location Secreted {ECO:0000250|UniProtKB:P97737}.
Tissue Location Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
Research Areas
Citations (0)
citation

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Background

GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.

References

Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000).
Hino, J., et al., Biochem. Biophys. Res. Commun. 223(2):304-310 (1996).
Cunningham, N.S., et al., Growth Factors 12(2):99-109 (1995).

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$ 365.00
$ 140.00
Cat# AP2060a
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