|Application ||WB, IHC-P, E|
|Calculated MW||45091 Da|
|Antigen Region||32-61 aa|
|Other Names||Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11, GDF11, BMP11|
|Target/Specificity||This GDF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human GDF11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GDF11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634).|
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Provided below are standard protocols that you may find useful for product applications.
GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
Lee, S.J., et al., Curr. Opin. Genet. Dev. 9(5):604-607 (1999).
McPherron, A.C., et al., Nat. Genet. 22(3):260-264 (1999).
Gamer, L.W., et al., Dev. Biol. 208(1):222-232 (1999).
Hillier, L.D., et al., Genome Res. 6(9):807-828 (1996).
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