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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HUMAN-SHB(Y268) Antibody   

HUMAN-SHB(Y268) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IHC-P - HUMAN-SHB(Y268) Antibody AP20620a
    Immunohistochemical analysis of paraffin-embedded H. small intestine section using Phospho-HUMAN-SHB(Y268). ctrl(Cat#AP20620a). AP20620a was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • FC - HUMAN-SHB(Y268) Antibody AP20620a
    Flow cytometric analysis of HepG2 cells using Phospho-HUMAN-SHB(Y268). ctrl(green, Cat#AP20620a) compared to an isotype control of rabbit IgG(blue). AP20620a was diluted at 1:25 dilution. An Alexa Fluor® 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.
  • WB - HUMAN-SHB(Y268) Antibody AP20620a
    Western blot analysis of lysates from HepG2, Jurkat, K562, HUVEC cell line (from left to right), using SHB-Y268 Antibody(Cat. #AP20620a). AP20620a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q15464
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 55042 Da
Additional Information
Gene ID 6461
Other Names SH2 domain-containing adapter protein B, SHB
Target/Specificity This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 250-290 amino acids from human.
Dilution IHC-P~~1:25
FC~~1:25
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHUMAN-SHB(Y268) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SHB
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

References

Welsh M.,et al.Oncogene 9:19-27(1994).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Karlsson T.,et al.Oncogene 10:1475-1483(1995).
Karlsson T.,et al.Oncogene 13:955-961(1996).

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$ 295.00
$ 99.00
Cat# AP20620a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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Ordering Information

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