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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RGS20 Antibody (Center)   

RGS20 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RGS20 Antibody (Center) AP20629c
    Western blot analysis of lysates from HepG2, U-87 MG cell line and human brain tissue lysate(from left to right), using RGS20 Antibody (Center)(Cat. #AP20629c). AP20629c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O76081
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43692 Da
Additional Information
Gene ID 8601
Other Names Regulator of G-protein signaling 20, RGS20, Gz-selective GTPase-activating protein, G(z)GAP, Gz-GAP, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, RGS20, RGSZ1, ZGAP1
Target/Specificity This RGS20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-184 amino acids from the Central region of human RGS20.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRGS20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RGS20
Synonyms RGSZ1, ZGAP1
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Cellular Location Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation.
Tissue Location Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe
Research Areas
Citations (0)

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Background

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).

References

Wang J.,et al.J. Biol. Chem. 273:26014-26025(1998).
Wang J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Barker S.A.,et al.Genomics 78:223-229(2001).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Glick J.L.,et al.J. Biol. Chem. 273:26008-26013(1998).

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$ 295.00
$ 99.00
Cat# AP20629c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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