RGS20 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | O76081 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 43692 Da |
Gene ID | 8601 |
---|---|
Other Names | Regulator of G-protein signaling 20, RGS20, Gz-selective GTPase-activating protein, G(z)GAP, Gz-GAP, Regulator of G-protein signaling Z1, Regulator of Gz-selective protein signaling 1, RGS20, RGSZ1, ZGAP1 |
Target/Specificity | This RGS20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 150-184 amino acids from the Central region of human RGS20. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RGS20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RGS20 |
---|---|
Synonyms | RGSZ1, ZGAP1 |
Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)- i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). |
Cellular Location | Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation. |
Tissue Location | Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
References
Wang J.,et al.J. Biol. Chem. 273:26014-26025(1998).
Wang J.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Barker S.A.,et al.Genomics 78:223-229(2001).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Glick J.L.,et al.J. Biol. Chem. 273:26008-26013(1998).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.