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BMP9 (GDF2) Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BMP9 (GDF2) Antibody (N-term) AP2064A
    The anti-hGDF2 N-term Pab (Cat. #AP2064a) is used in Western blot to detect hGDF2 in mouse liver tissue lysate.
    detail
  • WB - BMP9 (GDF2) Antibody (N-term) AP2064A
    Western blot analysis of GDF2 (arrow) using rabbit polyclonal GDF2-K23 (Cat. #AP2064a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GDF2 gene.
    detail
  • IHC-P - BMP9 (GDF2) Antibody (N-term) AP2064A
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
    detail
  • SPECIFICATION
  • CITATIONS: 2
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UK05
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 47320 Da
Antigen Region 8-37 aa
Additional Information
Gene ID 2658
Other Names Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9, GDF2, BMP9
Target/Specificity This BMP9 (GDF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human BMP9 (GDF2).
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBMP9 (GDF2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF2
Synonyms BMP9
Function Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
Cellular Location Secreted
Tissue Location Detected in blood plasma (at protein level).
Research Areas
Citations ( 0 )

Background

GDF2 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.

References

Majumdar, M.K., et al., J. Cell. Physiol. 189(3):275-284 (2001).
Lopez-Coviella, I., et al., Science 289(5477):313-316 (2000).
Miller, A.F., et al., J. Biol. Chem. 275(24):17937-17945 (2000).

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$ 365.00
$ 140.00
Cat# AP2064A
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