- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Calculated MW||47320 Da|
|Antigen Region||8-37 aa|
|Other Names||Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9, GDF2, BMP9|
|Target/Specificity||This BMP9 (GDF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human BMP9 (GDF2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMP9 (GDF2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.|
Provided below are standard protocols that you may find useful for product applications.
GDF2 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.
Majumdar, M.K., et al., J. Cell. Physiol. 189(3):275-284 (2001).
Lopez-Coviella, I., et al., Science 289(5477):313-316 (2000).
Miller, A.F., et al., J. Biol. Chem. 275(24):17937-17945 (2000).
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