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FATE1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - FATE1 Antibody (Center) AP20657c
    Western blot analysis of lysate from human testis tissue lysate, using FATE1 Antibody (Center)(Cat. #AP20657c). AP20657c was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q969F0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional Information
Other Names Fetal and adult testis-expressed transcript protein, Cancer/testis antigen 43, CT43, Tumor antigen BJ-HCC-2, FATE1, FATE
Target/Specificity This FATE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 107-140 amino acids from the Central region of human FATE1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFATE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FATE1
Synonyms FATE
Function Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER- mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).
Cellular Location Mitochondrion. Mitochondrion outer membrane. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER.
Tissue Location Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919) EMBL; AF249872; AAK69024.1; -; mRNA EMBL; AY101182; AAM48744.1; -; mRNA EMBL; AK057369; BAB71454.1; -; mRNA EMBL; BC022064; AAH22064.1; -; mRNA CCDS; CCDS14700.1; - RefSeq; NP_149076.1; NM_033085.2 UniGene; Hs.301960; - ProteinModelPortal; Q969F0; - SMR; Q969F0; - BioGrid; 124636; 67 IntAct; Q969F0; 111 MINT; Q969F0; - STRING; 9606.ENSP00000359375; - BioMuta; FATE1; - DMDM; 37078481; - PaxDb; Q969F0; - PeptideAtlas; Q969F0; - PRIDE; Q969F0; - ProteomicsDB; 75746; - DNASU; 89885; - Ensembl; ENST00000370350; ENSP00000359375; ENSG00000147378 GeneID; 89885; - KEGG; hsa:89885; - UCSC; uc004fex.4; human CTD; 89885; - DisGeNET; 89885; - EuPathDB; HostDB:ENSG00000147378.11; - GeneCards; FATE1; - HGNC; HGNC:24683; FATE1 HPA; HPA034604; - MIM; 300450; gene neXtProt; NX_Q969F0; - OpenTargets; ENSG00000147378; - PharmGKB; PA134875203; - eggNOG; ENOG410J190; Eukaryota eggNOG; ENOG410YXUY; LUCA GeneTree; ENSGT00390000006832; - HOGENOM; HOG000293282; - HOVERGEN; HBG051556; - InParanoid; Q969F0; - OMA; EQGATWR; - OrthoDB; EOG091G0QVT; - PhylomeDB; Q969F0; - TreeFam; TF338514; - ChiTaRS; FATE1; human GeneWiki; FATE1; - GenomeRNAi; 89885; - PRO; PR:Q969F0; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000147378; - CleanEx; HS_FATE1; - ExpressionAtlas; Q969F0; baseline and differential Genevisible; Q969F0; HS GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell GO; GO:0044233; C:ER-mitochondrion membrane contact site; IDA:UniProtKB GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB GO; GO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IDA:UniProtKB InterPro; IPR039153; FATE1 PANTHER; PTHR21128; PTHR21128; 1 1: Evidence at protein level; Apoptosis; Complete proteome; Endoplasmic reticulum; Membrane; Mitochondrion; Mitochondrion outer membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 183 Fetal and adult testis-expressed transcript protein /FTId=PRO_0000087200 TRANSMEM 163 181 Helical. VARIANT 10 10 A -> V (common polymorphism; 16% of the population; infertile and fertile individuals; dbSNP:rs3810715) /FTId=VAR_016917 VARIANT 34 34 I -> T (in fertile and infertile individuals) /FTId=VAR_016918 VARIANT 125 125 S -> R (in fertile and infertile individuals; dbSNP:rs141497002) /FTId=VAR_016919 MUTAGEN 151 151 L->D: Impairs association with mitochondria SEQUENCE 183 AA; 20712 MW; F3448EDCBCD148CB CRC64; MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ
Research Areas
Citations (0)

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References

Olesen C.,et al.Mol. Cell. Endocrinol. 184:25-32(2001).
Dong X.-Y.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Olesen C.,et al.Hum. Genet. 113:195-201(2003).

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$ 295.00
$ 99.00
Cat# AP20657c
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(40 western blots)
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