|Application ||WB, E|
|Other Names||Fetal and adult testis-expressed transcript protein, Cancer/testis antigen 43, CT43, Tumor antigen BJ-HCC-2, FATE1, FATE|
|Target/Specificity||This FATE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 107-140 amino acids from the Central region of human FATE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FATE1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER- mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).|
|Cellular Location||Mitochondrion. Mitochondrion outer membrane. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER.|
|Tissue Location||Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919) EMBL; AF249872; AAK69024.1; -; mRNA EMBL; AY101182; AAM48744.1; -; mRNA EMBL; AK057369; BAB71454.1; -; mRNA EMBL; BC022064; AAH22064.1; -; mRNA CCDS; CCDS14700.1; - RefSeq; NP_149076.1; NM_033085.2 UniGene; Hs.301960; - ProteinModelPortal; Q969F0; - SMR; Q969F0; - BioGrid; 124636; 67 IntAct; Q969F0; 111 MINT; Q969F0; - STRING; 9606.ENSP00000359375; - BioMuta; FATE1; - DMDM; 37078481; - PaxDb; Q969F0; - PeptideAtlas; Q969F0; - PRIDE; Q969F0; - ProteomicsDB; 75746; - DNASU; 89885; - Ensembl; ENST00000370350; ENSP00000359375; ENSG00000147378 GeneID; 89885; - KEGG; hsa:89885; - UCSC; uc004fex.4; human CTD; 89885; - DisGeNET; 89885; - EuPathDB; HostDB:ENSG00000147378.11; - GeneCards; FATE1; - HGNC; HGNC:24683; FATE1 HPA; HPA034604; - MIM; 300450; gene neXtProt; NX_Q969F0; - OpenTargets; ENSG00000147378; - PharmGKB; PA134875203; - eggNOG; ENOG410J190; Eukaryota eggNOG; ENOG410YXUY; LUCA GeneTree; ENSGT00390000006832; - HOGENOM; HOG000293282; - HOVERGEN; HBG051556; - InParanoid; Q969F0; - OMA; EQGATWR; - OrthoDB; EOG091G0QVT; - PhylomeDB; Q969F0; - TreeFam; TF338514; - ChiTaRS; FATE1; human GeneWiki; FATE1; - GenomeRNAi; 89885; - PRO; PR:Q969F0; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000147378; - CleanEx; HS_FATE1; - ExpressionAtlas; Q969F0; baseline and differential Genevisible; Q969F0; HS GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell GO; GO:0044233; C:ER-mitochondrion membrane contact site; IDA:UniProtKB GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB GO; GO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IDA:UniProtKB InterPro; IPR039153; FATE1 PANTHER; PTHR21128; PTHR21128; 1 1: Evidence at protein level; Apoptosis; Complete proteome; Endoplasmic reticulum; Membrane; Mitochondrion; Mitochondrion outer membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 183 Fetal and adult testis-expressed transcript protein /FTId=PRO_0000087200 TRANSMEM 163 181 Helical. VARIANT 10 10 A -> V (common polymorphism; 16% of the population; infertile and fertile individuals; dbSNP:rs3810715) /FTId=VAR_016917 VARIANT 34 34 I -> T (in fertile and infertile individuals) /FTId=VAR_016918 VARIANT 125 125 S -> R (in fertile and infertile individuals; dbSNP:rs141497002) /FTId=VAR_016919 MUTAGEN 151 151 L->D: Impairs association with mitochondria SEQUENCE 183 AA; 20712 MW; F3448EDCBCD148CB CRC64; MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ|
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Provided below are standard protocols that you may find useful for product applications.
Olesen C.,et al.Mol. Cell. Endocrinol. 184:25-32(2001).
Dong X.-Y.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Olesen C.,et al.Hum. Genet. 113:195-201(2003).
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