|Application ||WB, IHC-P, IF, E|
|Calculated MW||44552 Da|
|Antigen Region||1-412 aa|
|Other Names||Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD|
|Target/Specificity||This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between amino acids from human.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTSD Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.|
|Cellular Location||Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).|
|Tissue Location||Expressed in the aorta extrcellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).|
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Provided below are standard protocols that you may find useful for product applications.
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Faust P.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985).
Westley B.R.,et al.Nucleic Acids Res. 15:3773-3786(1987).
Redecker B.,et al.DNA Cell Biol. 10:423-431(1991).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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