|Application ||WB, IHC-P, E|
|Other Accession||O18831, Q95J86, O18836, Q9GM97|
|Predicted||Monkey, Pig, Bovine, Horse|
|Calculated MW||42750 Da|
|Antigen Region||9-38 aa|
|Other Names||Growth/differentiation factor 8, GDF-8, Myostatin, MSTN, GDF8|
|Target/Specificity||This Myostatin (GDF8) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-38 amino acids from the N-terminal region of human Myostatin (GDF8).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Myostatin (GDF8) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts specifically as a negative regulator of skeletal muscle growth.|
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Provided below are standard protocols that you may find useful for product applications.
GDF8 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
Hill, J.J., et al., J. Biol. Chem. 277(43):40735-40741 (2002). Hamrick, M.W., et al., Calcif. Tissue Int. 71(1):63-68 (2002). Welle, S., et al., Exp. Gerontol. 37(6):833-839 (2002). Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000). Ferrell, R.E., et al., Genomics 62(2):203-207 (1999).
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